| Date | Opponent* | Result | | |
| Sept. 5, 2009 | Montana St. | 12:00 pm ET | | |
| Sept. 12, 2009 | Central Michigan | 12:00 pm ET | | |
| Sept. 19, 2009 | at Notre Dame | 3:30 pm ET | | |
| Sept. 26, 2009 | at Wisconsin | TBA | | |
| Oct. 3, 2009 | Michigan | TBA | | |
| Oct. 10, 2009 | at Illinois | TBA | | |
| Oct. 17, 2009 | Northwestern | 12:00 pm ET | | |
| Oct. 24, 2009 | Iowa | 7:00 pm ET | | |
| Oct. 31, 2009 | at Minnesota | 8:00 pm ET | | |
| Nov. 7, 2009 | Western Michigan | TBA | | |
| Nov. 14, 2009 | at Purdue | TBA | | |
| Nov. 21, 2009 | Penn State | TBA |
B&G: Tim Prister-Irish Illustrated
B&G: Matt Lutovsky-Fantasy Football-Sporting News
B&G: Bill Garrity-ESPN College Football Insider
B&G: Scott Warheit- Tigers CutOff Man Blog
HUGE: Joe Rexrode-LSJ.com-MSU Football Insider
